Accession Number : ADA591365


Title :   Mutation of Breast Cancer Cell Genomic DNA by APOBEC3B


Descriptive Note : Annual summary 1 Sep 2012-31 Aug 2013


Corporate Author : MINNESOTA UNIV MINNEAPOLIS


Personal Author(s) : Burns, Michael B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a591365.pdf


Report Date : Sep 2013


Pagination or Media Count : 64


Abstract : Over the course of my tenure on this training grant, I have discovered that an endogenous enzyme, APOBEC3B, is upregulated in the majority of breast cancers. This holds true for both primary cancer tissues as well as cell lines. I have mechanistically characterized the enzyme s activity, sub-cellular localization, preferred sequence substrate and kinetics, and impact on the cancer cell genome. In addition, I have expanded my research to include all of the available cancer types represented in the publicly accessible portion of The Cancer Genome Atlas (TCGA). Using the massive data repository, I have found that the same mutational phenomenon that I have identified in breast cancer is also at work in 5 other types of cancer: head & neck cancer, cervical cancer, bladder cancer, squamous cell lung cancer and lung adenocarcinomas.


Descriptors :   *BREAST CANCER , BLADDERS , CELLS , CELLS(BIOLOGY) , DEOXYRIBONUCLEIC ACIDS , GENOME , LUNG CANCER , MUTATIONS , NECK(ANATOMY) , TISSUES(BIOLOGY)


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE