Accession Number : ADA591280


Title :   Cancer and Stroma-Targeted Immunotherapy with a Genetically Modified DC Vaccine


Descriptive Note : Final rept. 1 May 2010-30 Apr 2013


Corporate Author : BAYLOR COLL OF MEDICINE HOUSTON TX


Personal Author(s) : Song, Xiao-Tong


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a591280.pdf


Report Date : May 2013


Pagination or Media Count : 45


Abstract : While current DC vaccines are safe, their antitumor activity is limited. This is foremost due to the presence of regulatory T cells (Tregs), which create an immunosuppressive environment in breast cancer patients. In addition, there is increasing evidence that effective solid tumor vaccines have to target cancer cells as well as their supporting stroma. Thus, overcoming Treg mediated immune suppression and targeting the tumor stroma in addition to breast cancer cells may produce the desired increase in antitumor activity of DC vaccines for breast cancer. Recombinant lentiviral vector expressing A20-shRNA, HER2 and FAP was prepared and 4T1.2-neu tumor bearing mice were immunized with the lentivirus transduced DC vaccine. We found the DC vaccine induced robust T cell responses against HER2 and FAP, resulting in enhanced antitumor effect. Thus, the DC vaccine that target not only HER2, but also Treg and FAP, might present the optimized DC vaccine strategy against HER2+ breast cancer.


Descriptors :   *BREAST CANCER , *IMMUNOTHERAPY , *T LYMPHOCYTES , ANTIBODIES , IMMUNOSUPPRESSION , TARGETING , VACCINES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE