Accession Number : ADA590498


Title :   Advanced MRI in Acute Military TBI


Descriptive Note : Annual rept. 1 Sep. 2012-31 Aug 2013


Corporate Author : WASHINGTON UNIV ST LOUIS MO


Personal Author(s) : Brody, David L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a590498.pdf


Report Date : Sep 2013


Pagination or Media Count : 66


Abstract : The objective of the project is to test two advanced MRI methods, DTI and resting-state fMRI correlation analysis, in military TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. An additional objective is to test the interaction of candidate genetic vulnerability factors with patterns of injury. These combined methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis is that traumatic axonal injury, interacting with genetic vulnerability factors, is a principal cause of impaired brain function following blast-related and non-blast-related TBI. The study is a prospective longitudinal study with subject enrollment and initial evaluation at Landstuhl Regional Medical Center in Landstuhl Germany and at 2 sites in Afghanistan. Follow-up evaluations are performed at Washington University in St Louis. We have closed enrollment in all sites as of June 1, 2013. 255 subjects were enrolled at LRMC and 230 subjects were enrolled in Afghanistan. 177 subjects enrolled at LRMC and 70 subjects enrolled in Afghanistan have completed follow-up evaluations There have been no adverse events.


Descriptors :   *MAGNETIC RESONANCE IMAGING , *MILITARY PERSONNEL , *TRAUMATIC BRAIN INJURIES , BLAST , MILITARY MEDICINE , POST TRAUMATIC STRESS DISORDER


Subject Categories : Medicine and Medical Research
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE