Accession Number : ADA589556


Title :   Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD


Personal Author(s) : McNutt, Patrick M ; Tuznik, Kaylie ; Nelson, Marian ; Adkins, Angie ; Lyman, Megan ; Glotfelty, Elliot ; Hughes, James ; Hamilton, Tracey


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a589556.pdf


Report Date : Oct 2013


Pagination or Media Count : 11


Abstract : Sulfur mustard (SM) is a highly reactive vesicant that causes severe ocular injuries. Following exposure to moderate or high doses, a subset of victims develops a chronic injury known as mustard gas keratopathy (MGK) involving a keratitis of unknown etiopathogenesis with secondary keratopathies such as persistent epithelial lesions, corneal neovascularization, and progressive corneal degeneration. This study was designed to determine whether SM exposure evokes acute endothelial toxicity and to determine whether endothelial pathologies were specifically observed in MGK corneas as opposed to healed corneas.


Descriptors :   *CORNEA , *MUSTARD AGENTS , *SULFUR , DOSAGE , ENDOTHELIUM , EPITHELIUM , EXPOSURE(PHYSIOLOGY) , EYE , GASES , LESIONS , REACTIVITIES , TOXICITY , VAPORS


Subject Categories : Medicine and Medical Research
      Military Operations, Strategy and Tactics


Distribution Statement : APPROVED FOR PUBLIC RELEASE