Accession Number : ADA587633


Title :   Metal Ion-Catalyzed Alcoholysis as a Strategy for the High Loading Destruction of Chemical Warfare Organophosphorus Agents


Descriptive Note : Final rept. Aug 2009-Nov 2010


Corporate Author : ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD RESEARCH AND TECHNOLOGY DIR


Personal Author(s) : Durst, H D ; Brown, R S ; Neverov, Alexei A ; Tamer, Andrea


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a587633.pdf


Report Date : Nov 2013


Pagination or Media Count : 54


Abstract : Metal-catalyzed alcoholysis has proven to be an effective strategy for the rapid transformation of neutral reactive organophosphate esters of the phosphate, phosphonate, phosphorothioate, and phosphonothioate classes. This chemistry, using La(expn 3+) ( OMe)/Methanol as catalyst/solvent, applied to the V and G classes of chemical warfare agents, demonstrated extremely rapid transformation to low toxicity esters with load factors of 30% for non-fluoride-releasing agents. Variation of the alcohol solvent is tolerated. Variations of the metal catalyst provide potential redress to the fluoride inhibition of the G agent class. These observations indicate that formulations based on mixed alcohol solvents combined with optimized metal catalysts for use in field decontamination, civilian security, and infrastructure scenarios provide a pathway for tuning the reaction media while retaining extremely rapid destruction kinetics.


Descriptors :   *CHEMICAL WARFARE AGENTS , *ORGANOPHOSPHATES , CATALYSIS , DECONTAMINATION , G AGENTS , IONS , METHANOLS , PESTICIDES , SOLVENTS , V AGENTS


Subject Categories : Organic Chemistry
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE