Accession Number : ADA587607


Title :   Advances in Synthetic Peptides Reagent Discovery


Descriptive Note : Journal article


Corporate Author : ARMY RESEARCH LAB ADELPHI MD


Personal Author(s) : Adams, Bryn L ; Sarkes, Deborah A ; Finch, Amethist S ; Stratis-Cullum, Dimitra N


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a587607.pdf


Report Date : Jul 2013


Pagination or Media Count : 16


Abstract : Bacterial display technology offers a number of advantages over competing display technologies (e.g, phage) for the rapid discovery and development of peptides with interaction targeted to materials ranging from biological hazards through inorganic metals. We have previously shown that discovery of synthetic peptide reagents utilizing bacterial display technology is relatively simple and rapid to make laboratory automation possible. This included extensive study of the protective antigen system of Bacillus anthracis, including development of discovery, characterization, and computational biology capabilities for in-silico optimization. Although the benefits towards CBD goals are evident, the impact is far-reaching due to our ability to understand and harness peptide interactions that are ultimately extendable to the hybrid biomaterials of the future. In this paper, we describe advances in peptide discovery including, new target systems (e.g. non-biological materials), advanced library development and clone analysis including integrated reporting.


Descriptors :   *PEPTIDES , AUTOMATION , BACTERIA , COMPUTATIONS , INORGANIC MATERIALS , METALS


Subject Categories : Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE