Accession Number : ADA585392


Title :   Nanomedicine for Early Disease Detection and Treatment


Descriptive Note : Final rept. 15 Aug 2011-14 Aug 2013


Corporate Author : METHODIST HOSPITAL HOUSTON TX


Personal Author(s) : Tung, Ching-Hsuan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a585392.pdf


Report Date : Sep 2013


Pagination or Media Count : 51


Abstract : A platform technology to prepare enzyme sensitive nanomedicine (ESNM), which integrates the imaging and treatment capability, has been developed to report and cure diseases. ESNM is prepared with multiple layers of polyelectrolytes, sequentially assembled on an inert gold nanoparticle, using alternating charged polymers. Potentially the release kinetics could be controlled by varying polyelectrolytes with different properties, such as length, ionic strength and bond stability. Upon incubation with cells, the assembled ESNMs are taken up efficiently. The tight packing and layered assembly of the quenched polyelectrolytes slow subsequent intracellular degradation, and


Descriptors :   *MEDICAL SERVICES , *PEPTIDE HYDROLASES , *RIBONUCLEIC ACIDS , ACTIVATION , ASSEMBLY , BONDING , DELIVERY , DISEASES , KINETICS , PACKAGING , POLYELECTROLYTES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE