Accession Number : ADA585061


Title :   Catecholamines in Post-Traumatic Stress Disorder


Descriptive Note : Final rept. 1 Jul 2008-30 Jun 2012


Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA


Personal Author(s) : Thomas, Steven A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a585061.pdf


Report Date : Jul 2012


Pagination or Media Count : 16


Abstract : The purpose of these studies is to test the hypothesis that adrenergic and dopaminergic signaling contribute to consolidation (and possibly reconsolidation) of fear memory in a redundant manner by stimulation of beta2-adrenergic and the D1-class of dopaminergic receptors in the basolateral amygdala. Combined pharmacologic and genetic studies in mice have examined the above hypothesis for the consolidation of fear memory. The results are in agreement with the hypothesis. Roles for these signaling pathways in reconsolidation are not as clear, as combined treatment does not appear to influence reconsolidation. Current results indicate that treatment with beta-adrenergic receptor antagonists (beta-blockers) alone shortly after trauma is unlikely to prevent the development of PTSD. However, combination therapy of blockers and D1 receptor antagonists shortly after trauma may reduce the incidence of PTSD.


Descriptors :   *CATECHOLAMINES , *POST TRAUMATIC STRESS DISORDER , DOPAMINE , GENETICS , HYPOTHESES , PHARMACOLOGY , RECEPTOR SITES(PHYSIOLOGY) , REDUNDANCY , SIGNALS , SYMPATHOLYTIC AGENTS , TEST AND EVALUATION , THERAPY , TRAUMA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE