Accession Number : ADA584963


Title :   Analysis of the Small Intestinal Microbiome of Children With Autism


Descriptive Note : Final rept. 15 Jun 2010-14 Apr 2013


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Kushak, Rafail


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a584963.pdf


Report Date : May 2013


Pagination or Media Count : 22


Abstract : The entire microbial population of the duodenal mucosa of subjects with autism was analyzed to determine if there was an overgrowth of a specific populations of bacteria in comparison with unaffected subjects. Patient information, disaccharidase test results, and microbiome analysis were used for group comparison. Duodenal microbiota in autistic individuals was studied for the first time. Study population was represented by 21 autistic subjects and 19 unaffected subjects. Individuals in both groups had GI symptoms. Mucosa-associated microbiota in the duodenum was represented by Bacteroidetes, Firmicutes, and Proteobacteria with no statistically significant difference between groups on fyla level. Numbers of bacteria of Pedobacter genus was significantly higher in subjects with autism but genera Neisseria, Shigella, Blautia, and Enterobacter were less abundant in autistic subjects than in controls. Statistically significant difference between autistic and non-autistic subjects was found for eight bacterial species. There was a correlation between disaccharidase activity (particularly lactase) and duodenal microbiota.


Descriptors :   *CHILDREN , *DUODENUM , *SMALL INTESTINE , BACTERIA , COMPARISON , CONTROL , CORRELATION , DISACCHARIDES , ENTEROBACTERIACEAE , MICROORGANISMS , MUCOUS MEMBRANES , PATIENTS , TEST AND EVALUATION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE