Accession Number : ADA582141


Title :   Fatty Acid Synthase Activity as a Target for c-Met Driven Prostate Cancer


Descriptive Note : Annual summary rept. 1 July 2011 - 30 June 2013


Corporate Author : LOUISIANA STATE UNIV IN SHREVEPORT HEALTH SCIENCE CENTER


Personal Author(s) : Coleman, David T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a582141.pdf


Report Date : Jul 2013


Pagination or Media Count : 233


Abstract : The overarching goal of this project is to understand the mechanism by which fatty acid synthase (FASN) activity regulates the expression levels of the oncogenic cmet receptor tyrosine kinase in prostate cancer. My earlier work identified a connection between FASN activity and c-Met protein expression; and more recent data from this reporting period strongly suggests FASN-derived palmitate is required as a post-translation modification to c-Met in order to maintain its stability and trafficking to the plasma membrane. Conclusive evidence for this regulatory mechanism would implicate fatty acid synthase activity and/or palmitoylation as unique therapeutic targets for reducing c-Met expression.


Descriptors :   *PROSTATE CANCER , FATTY ACIDS , SYNTHASES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE