Accession Number : ADA581127


Title :   Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury


Descriptive Note : Annual rept. 2012-28 Feb 2013


Corporate Author : GENEVA FOUNDATION TACOMA WA


Personal Author(s) : Long, Joseph


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a581127.pdf


Report Date : Mar 2013


Pagination or Media Count : 84


Abstract : We hypothesize that the biomechanical perturbations of the brain that yield blastinduced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure (BOP) (i.e. primary blast) and head acceleration and/or impact (i.e. tertiary blast). The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.


Descriptors :   *BRAIN , *MEDICAL RESEARCH , *TRAUMATIC BRAIN INJURIES , BIOMECHANICS , BLAST , CONTROL , IMPACT , MODELS , PERTURBATIONS , RODENTS , TRAUMA , WOUNDS AND INJURIES , YIELD


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE