Accession Number : ADA579836


Title :   Melanocortin and Opioid Peptide Interactions in the Modulation of Binge Alcohol Drinking


Descriptive Note : Final rept. 23 Mar 2009-22 Mar 2013


Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL


Personal Author(s) : Thiele, Todd E ; Thiele, Montserrat N ; Picker, Mitchell J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a579836.pdf


Report Date : Apr 2013


Pagination or Media Count : 97


Abstract : Frequent binge drinking is associated with numerous negative short- and long-term consequences, including an increased risk of accidental injury, violent behavior, depression, heart disease, and type 2 diabetes. While illicit drug use and cigarette smoking both decreased significantly in the US military between the period of 1980 to 2002, heavy alcohol use increased. In fact, heavy alcohol use and binge drinking are observed in 27% of the military population. Identifying neurochemical pathways in the brain that modulate binge drinking may provide insight into pharmaceutical treatments that could protect against this dangerous behavior. Recently identified candidates for modulating binge drinking are the melanocortin (MC) peptides, such as -melanocyte stimulating hormone ( -MSH), and the opioid peptide -endorphin which are produced in the same brain neurons. The specific aims proposed below will test the guiding hypothesis that stimulation of MC receptor and blockade of opioid receptor protect against excessive binge-like alcohol drinking and intoxicating blood alcohol levels (BALs) in an animal model of binge drinking. The aims will also determine if MC receptor (MCR) agonists and opioid receptor antagonists interact to protect against binge-like alcohol drinking in a synergistic manner.


Descriptors :   *ALCOHOLISM , *CARDIOVASCULAR DISEASES , *HEART , ALCOHOLS , BLOOD VOLUME , BRAIN , DRUGS , ETHANOLS , HYPOTHESES , INGESTION(PHYSIOLOGY) , MICE , MILITARY PERSONNEL , NARCOTICS , NERVE CELLS , NEUROCHEMISTRY , PHARMACOLOGICAL ANTAGONISTS , RECEPTOR SITES(PHYSIOLOGY) , RISK , SENSE ORGANS , SYNERGISM , TEST AND EVALUATION , TOBACCO SMOKING


Subject Categories : Psychology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE