Accession Number : ADA577325


Title :   Early Whole Blood for Patients Requiring Massive Transfusion after Major Trauma


Descriptive Note : Addendum to final rept. 1 Mar 2012-28 Feb 2013


Corporate Author : TEXAS UNIV AT AUSTIN


Personal Author(s) : Cotton, Bryan A ; Wade, Charles E ; Kozar, Rosemary A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a577325.pdf


Report Date : Mar 2013


Pagination or Media Count : 13


Abstract : Severe uncontrollable coagulopathy in major trauma patients continues to be a major factor in trauma mortalities. This proposal will implement a randomized, controlled trial of early whole blood transfusions in high risk, major trauma patients to determine if whole blood can prevent or control severe coagulopathy compared to standard massive transfusion care (currently 1:1 ratio of FFP to PRBC). Second, this proposal will determine if we can accurately predict major trauma patients who will require massive transfusion within 20 minute of arrival to the emergency department. Finally, this study aims to test commonly utilized point of care analysis and determine its reliability in early prediction of transfusion needs. Two connected sub-projects under the leadership of Dr. Charles Wade and Dr. Rosemary Kozar are associated with this project and are further discussed in the text of the report.


Descriptors :   *BLOOD TRANSFUSION , *TRAUMA , BLOOD , BLOOD COAGULATION , MORTALITY RATE , PATIENTS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE