Accession Number : ADA577054


Title :   Controlled Enhancemnt of Long-Term Memory by Modulating Neuronal miRNA Function


Descriptive Note : Final rept. 1 Nov 2007-30 Apr 2009


Corporate Author : SCIENCE APPLICATIONS INTERNATIONAL CORP SAN DIEGO CA


Personal Author(s) : Griffey, Richard


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a577054.pdf


Report Date : 20 Sep 2012


Pagination or Media Count : 12


Abstract : The modulation of long-term memory formation in a mouse model has been evaluated following administration of antisense oligonucleotides targeting mRNA from Calcineurin, p250GAP, Armitage, Cbl-b, and CREB-BP in the brain. Alzet minipumps containing stable phosphorothioate antisense oligonucleotides for the 5 targets and a control oligonucleotide were implated in the brains of 51 C57B16 male mice. Following recovery, animals were trained for 3 days, and memory formation was assessed after 3 days, 3 weeks, and 7 weeks. Sustained knock-down of Cbl-b statistically enhanced 24 hr and 3 week memory, but produced histological changes in the brains of treated animals.


Descriptors :   *MEMORY(PSYCHOLOGY) , *RIBONUCLEIC ACIDS , ANATOMICAL MODELS , ANIMALS , BRAIN , HISTOLOGY , MEMORY DEVICES , NUCLEOTIDES , OLIGOMERS , PHOSPHOROTHIOATES , RECOVERY , RETENTION(PSYCHOLOGY) , STABILITY , TARGETING


Subject Categories : Psychology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE