Accession Number : ADA576147


Title :   Spreading Depressions as Secondary Insults after Traumatic Injury to the Human Brain


Descriptive Note : Annual rept. 1 Sep 2011-31 Aug 2012


Corporate Author : CINCINNATI UNIV OH


Personal Author(s) : Hartings, Jed A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a576147.pdf


Report Date : Sep 2012


Pagination or Media Count : 61


Abstract : This report describes year 4 progress of a multi-center study of neurosurgical TBI patients to determine the effects of spreading depression (SD), measured by electrocorticography, on neurologic outcome. In this year, we have enrolled 42 patients, bringing the study total to 136. Data collection, scoring, and monitoring has been completed for 90 patients. Using data from the present study combined with the pilot study, we published the finding that SD is independently associated with worse outcomes in 103 patients. These results establish SD as a mechanism of secondary injury. These analyses will be repeated with the full cohort from the present study and an advanced prognostic model will be developed based on more refined metrics of SD burden, secondary insults, and TBI pathoanatomy. Overall progress indicates that SD should be targeted therapeutically in a future interventional trial. We also found evidence that SD can be monitored non-invasively by scalp EEG recordings, thus providing a method to extend results to non-surgical TBI patients.


Descriptors :   *BRAIN , *TRAUMATIC BRAIN INJURIES , *WOUNDS AND INJURIES , DATA ACQUISITION , DEPRESSION , ELECTROENCEPHALOGRAPHY , HEAD(ANATOMY) , HYPOTENSION , MONITORING , PATIENTS , RECORDING SYSTEMS , SKIN(ANATOMY) , TRAUMA


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE