Accession Number : ADA574565


Title :   Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury


Descriptive Note : Annual rept. 30 Sep 2011-29 Oct 2012


Corporate Author : UTAH UNIV SALT LAKE CITY


Personal Author(s) : Brennan, K C ; Dudek, Ed ; Pouliot, Wendy ; Vargas, Jay ; Mendez, Jorge M ; Sawant, Punam


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a574565.pdf


Report Date : Oct 2012


Pagination or Media Count : 60


Abstract : Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important milestones have been the validation and beginning of data collection for remote telemetric monitoring and two-photon microscopy. These are both technology-intensive, cutting edge techniques, and two-photon microscopy was a new technique for our group. We have also collected publication-ready work using our more familiar optical imaging techniques, showing that the immunological activation associated with TBI alters brain excitability.


Descriptors :   *EPILEPSY , *TRAUMATIC BRAIN INJURIES , BRAIN , CUTTERS , DATA ACQUISITION , IMMUNOLOGY , MICROSCOPY , MONITORING , NATURAL HISTORY , OPTICAL IMAGES , PHOTONS , REMOTE DETECTION , TELEMETER SYSTEMS , THERAPY , TRAUMA , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE