Accession Number : ADA574012


Title :   Inactivation of Aerosolized Biological Agents using Filled Nanocomposite Materials


Descriptive Note : Technical rept. 28 Jan 2008-8 Jul 2011


Corporate Author : CINCINNATI UNIV OH


Personal Author(s) : Grinshpun, S A ; Schoenitz, M ; Dreizin, E ; Adhikari, A ; Reponen, T ; Yermakov, M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a574012.pdf


Report Date : Feb 2013


Pagination or Media Count : 139


Abstract : In this multi-institutional grant, a new method for inactivating aerosolized biological agents was developed utilizing a new class of energetic materials: filled nanocomposite materials. The implemented approach enabled a controllable release of iodine-based oxidizing species in the combustion environment to inactivate viable airborne bio-agents, such as stress-resistant bacterial spores and viruses. Composites with adjustable Al/I2 ratios were produced. A state-of-the-art experimental facility was developed for studying how novel energetic formulations and their combustion products affect the viability of aerosolized spores and viruses during a short ( 1 s) exposure times. Controlled bioaerosol dispersal and sample collection protocols were developed and optimized. The dry-heat inactivation of aerosolized spores was quantified separately from chemical effects and linked to DNA repair mechanisms. It was concluded that the iodine-containing powder provided significantly more effective inactivation of airborne spores than non-iodinated powders. The results of this research help to better understand physical, physicochemical, and biological properties associated with inactivation of aerosolized bio-agents in combustion environments.


Descriptors :   *BIOLOGICAL AGENTS , *COMPOSITE MATERIALS , AIR FLOW , AIRBORNE , BACILLUS SUBTILIS , BIOLOGICAL AEROSOLS , COMBUSTION , ENERGETIC PROPERTIES , IODINE , PATHOGENIC MICROORGANISMS , SPORES , VIRUSES


Subject Categories : Microbiology
      Laminates and Composite Materials


Distribution Statement : APPROVED FOR PUBLIC RELEASE