Accession Number : ADA573591


Title :   Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury


Descriptive Note : Annual rept. 30 Sep 2011-29 Sep 2012


Corporate Author : STATE UNIV OF NEW YORK DOWNSTATE MEDICAL CENTER BROOKLYN


Personal Author(s) : Bergold, Peter


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a573591.pdf


Report Date : Oct 2012


Pagination or Media Count : 14


Abstract : Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Four tasks will be done to achieve this objective: 1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following moderate CCI. 2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3) TBI is clinically heterogenous; MINO/NAC should restore brain function following an additional TBI model, lateral fluid percussion. 4) A restoration of cognitive function will be tested three months after CCI. The grantee has received both institutional and DoD approval for the animal experiments in this work and has trained a MD-Ph.D. candidate to perform these studies.


Descriptors :   *TRAUMATIC BRAIN INJURIES , BRAIN , DOSAGE , DRUGS , HISTOLOGY , SYNERGISM , TRAINING , TRAUMA , WOUNDS AND INJURIES


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE