Accession Number : ADA573505


Title :   A Search for Gene Fusions/Translocations in Breast Cancer


Descriptive Note : Annual rept. 1 Sep 2011-31 Aug 2012


Corporate Author : MICHIGAN UNIV ANN ARBOR


Personal Author(s) : Chinnaiyan, Arul M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a573505.pdf


Report Date : Oct 2012


Pagination or Media Count : 41


Abstract : Previously, we completed the molecular/ biochemical characterization of several shortlisted candidate gene fusions from the transcriptome sequencing of over 70 previously validated samples. From these studies, we identified two rare but recurrent gene fusions in breast cancer cell lines and tissues involving the MAST and Notch genes. Both of these fusion genes are potentially targetable and patients harboring MAST or Notch fusions may benefit from MAST or Notch inhibitors. Functional characterizations of the fusion genes in various in vivo and in vitro assays are ongoing. In this reporting period of our ongoing project, Search for Gene Fusions/Translocations in Breast Cancer , we extended upon the analysis of gene fusions in breast cancer to examine amplicon-associated gene fusions and their functional significant. We also describe a novel study of cancer-specific pseudogenes.


Descriptors :   *BIOCHEMISTRY , *BREAST CANCER , *GENES , IN VITRO ANALYSIS , IN VIVO ANALYSIS , INHIBITORS , MASTS , TISSUES(BIOLOGY)


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE