Accession Number : ADA571883


Title :   Developing Breast Cancer Program at Xavier; Genomic and Proteomic Analysis of Signaling Pathways Involved in Xenohormone and MEK5 Regulation of Breast Cancer


Descriptive Note : Final rept. 19 Apr 2004-18 Apr 2010


Corporate Author : XAVIER UNIV OF LOUISIANA NEW ORLEANS


Personal Author(s) : Wiese, Thomas E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a571883.pdf


Report Date : May 2010


Pagination or Media Count : 36


Abstract : Xavier University (XU) and the Tulane Cancer Center (TCC) will build a core of human talent that will address scientific problems such as drug resistance and the effect of environmental agents on breast cancer (BC) in the African- American community. A multi-part research and training program will generate data, develop new research programs and train new faculty and African-American students in BC research. The first component will fund two research projects. The Wang and Burow project will elucidate a previously unexplored cellular signaling mechanism that leads to drug resistance in breast carcinoma cells derived from African American women and women of other ethnicities. The Wiese and Hill project will identify and characterize the genes and gene products associated with BC cell proliferation induced by exposure to pesticide mixtures and is relevant to the African American community in Southern States where pesticide exposure is relatively high. The second part of the program aims to increase the number of faculty at XU involved in BC research by supporting two junior faculty members to develop BC research projects with a TCC mentor. The third objective will support research training of XU undergraduates and pharmacy students. The fourth objective will provide workshops, seminars and research opportunities in BC research for the XU community. This program will enhance the understanding of unique aspects of BC development and progression among African American women and will contribute to the elimination of the mortality gap between African- American BC patients and women of other ethnicities.


Descriptors :   *BREAST CANCER , *CORES , *DRUGS , *GENES , *PESTICIDES , *PROTEOMICS , AFRICAN AMERICANS , CELLS(BIOLOGY) , COMMUNITIES , ESTROGENS , PATIENTS , PHARMACIES , RESEARCH MANAGEMENT , RESISTANCE(BIOLOGY) , STUDENTS , SYMPOSIA , TRAINING , UNIVERSITIES


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE