Accession Number : ADA571654
Title : Analysis of Sertraline in Postmortem Fluids and Tissues in 11 Aviation Accident Victims
Descriptive Note : Final rept.
Corporate Author : FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROSPACE MEDICAL INST
Personal Author(s) : Lewis, Russell J ; Angier, Mike K ; Williamson, Kelly S ; Johnson, Robert D
Report Date : Nov 2012
Pagination or Media Count : 18
Abstract : Sertraline (Zoloft R) is a selective serotonin reuptake inhibitor that is a commonly prescribed drug for the treatment of depression, as well as obsessive-compulsive disorder, panic disorder, social anxiety disorder, premenstrual dysphoric disorder, and post-traumatic stress disorder. While the use of sertraline is relatively safe, certain side effects could negatively affect a pilot's performance and become a factor in an aviation accident. The adverse side effects associated with this medication include: sleepiness, nervousness, insomnia, headaches, tremors, and dizziness. The nature of aviation accidents often precludes the availability of blood from accident victims; therefore, tissues must be relied upon for analysis. Understanding the distribution of a drug throughout postmortem fluids and tissues is important when trying to interpret drug impairment and/or intoxication. Our laboratory investigated the distribution of sertraline and its primary metabolite, desmethylsertraline, in various postmortem tissues and fluids obtained from 11 fatal aviation accident cases between 2001-2004. The gender of the pilots was male and their ages ranged from 31-66. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, liver, lung, kidney, spleen, muscle, brain, heart, and bile. Human specimens were processed utilizing solid-phase extraction, followed by characterization and quantitation employing GC/MS. Whole blood sertraline concentrations obtained from these 11 cases ranged from 0.005 to 0.392 micg/mL. The distribution of sertraline, expressed as specimen/blood ratio, was as follows: urine 0.47 +/-0.39 (n=6), vitreous humor 0.02 +/- 0.01 (n=4), liver 74 +/- 59 (n=11), lung 67 +/- 45 (n=11), kidney 7.4 +/- 5 (n=11), spleen 46 +/- 45 (n=10), muscle 2.1 +/- 1.3 (n=8), brain 22 +/- 14 (n=10), heart 9 +/- 7 (n=11), and bile 36 +/- 26 (n=8).
Descriptors : *ANTIDEPRESSANTS , *TOXICOLOGY , AUTOPSY , AVIATION ACCIDENTS , CALIBRATION , FORENSIC ANALYSIS , GAS CHROMATOGRAPHY , MASS SPECTROSCOPY , PILOTS , STRESS(PHYSIOLOGY) , TISSUES(BIOLOGY)
Subject Categories : Toxicology
Distribution Statement : APPROVED FOR PUBLIC RELEASE