Accession Number : ADA571158


Title :   Agents Within our Midst


Descriptive Note : Final rept. 15 Dec 2006-14 Dec 2012


Corporate Author : NEW YORK STRUCTURAL BIOLOGY CENTER INC NEW YORK NY


Personal Author(s) : Goger, Michael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a571158.pdf


Report Date : 14 Mar 2012


Pagination or Media Count : 16


Abstract : The New York Structural Biology Center (NYSBC), a leading center in magnetic resonance spectroscopy and X-ray crystallography, has worked with researchers at Albert Einstein College of Medicine (AECOM), and scientists at the Edgewood Chemical Biological Center (ECBC) in several projects whose objective is the analysis of the chemical and biological makeup of warfare agents. The projects include: the structural analysis of Staphylococcal Enterotoxin B (SEB), considered to be a potential biological threat with particular potency on the battlefield; the analysis of recognition molecules for use in automated detection devices that are sensitive to biological toxins that could be deployed in public places; the identification of genes that are candidate targets for potential drugs to counteract pathogens that could be used as warfare agents; the reactions of man made surfaces to chemicals used for decontaminating after exposure to chemical warfare agents; and the development of bio-monitoring protocols for civilian and service personnel during a chemical attack. These efforts have resulted in greater knowledge about the behavior of biological and chemical warfare agents in the environment. This knowledge will help facilitate their detection and the design and development of countermeasures for application to battlefield defense and homeland security.


Descriptors :   *CRYSTALLOGRAPHY , *ENTEROTOXINS , *PATHOGENIC MICROORGANISMS , *STAPHYLOCOCCUS , *X RAYS , BIOLOGICAL WARFARE , CHEMICAL WARFARE , CHEMICAL WARFARE AGENTS , CHEMICALS , DECONTAMINATION , DEFENSE SYSTEMS , DEPLOYMENT , DRUGS , HOMELAND SECURITY , MAGNETIC RESONANCE IMAGING , MILITARY PERSONNEL , MOLECULES , SPECTROSCOPY , STRUCTURAL ANALYSIS , TOXINS AND ANTITOXINS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE