Accession Number : ADA571105


Title :   Glycomic Analysis of Prostate Cancer


Descriptive Note : Final rept. 1 Jul 2009-30 Jun 2012


Corporate Author : GEORGETOWN UNIV WASHINGTON DC


Personal Author(s) : Goldman, Radoslav


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a571105.pdf


Report Date : Jul 2012


Pagination or Media Count : 17


Abstract : We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions; analysis of the IgA/IgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.


Descriptors :   *PROSTATE CANCER , AFRICAN AMERICANS , CAUCASIANS , FRACTIONATION , GENE EXPRESSION , IMMUNOGLOBULINS , PROTEINS , RIBONUCLEIC ACIDS , RISK


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE