Accession Number : ADA570603


Title :   Defining Genomic Changes in Triple-Negative Breast Cancer in Women of African Descent


Descriptive Note : Final rept. 1 Jun 2009-31 May 2012


Corporate Author : MIAMI UNIV FL


Personal Author(s) : Baumbach, Lisa L ; Begram, Mark


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a570603.pdf


Report Date : Jun 2012


Pagination or Media Count : 12


Abstract : Breast cancer (BC) is the second leading cause of cancer death among African-American (AA) women, with mortality 20% greater than that in Caucasians (Cauc). However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of unidentified genes contributing to AA BC risk. Matched tumor and normal FFPE samples from Cauc and AA patients were obtained from the UM /Sylvester Breast Tissue Bank (UM/S BTB) under an IRB-approved protocol. Based on analysis of 22,000 transcripts, ethnic specific gene expression patterns were identified that may provide important new insights into molecular mechanisms of ethnic subtype differences in clinical outcomes. We propose to extend these preliminary findings to a large African tumor bank [available via collaboration between Drs. Peter A. Bird (Kijabe, Kenya) and Mark Pegram (UM Sylvester).] Additionally, we propose to analyze chromosomal alterations associated with gene expression differences utilizing array cGH (in collaboration with Alan Ashworth, England). This work will contribute to development of rationale designs of preventive, predictive and therapeutic measures for BC in different ethnicities, and thus, a significant reduction in current ethnic-specific disparities in BC incidence, morbidity and mortality.


Descriptors :   *BREAST CANCER , *CHROMOSOMES , *DEATH , *TISSUES(BIOLOGY) , AFRICA , AFRICAN AMERICANS , ALCOHOLISM , CAUCASIANS , CHANGE DETECTION , GENES , GENOME , KENYA , MOLECULAR PROPERTIES , MORBIDITY , MORTALITY RATE , NEOPLASMS , PATIENTS , SAMPLING , THERAPY , TISSUE BANKS , UNITED KINGDOM , WOMEN


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE