Accession Number : ADA570345


Title :   Identification of Genes and Genetic Variants Associated with Poor Treatment Response in Patients with Prostate Cancer


Descriptive Note : Annual rept. 30 Sep 2011-29 Sep 2012


Corporate Author : UTAH UNIV SALT LAKE CITY


Personal Author(s) : Cannon-Albright, Lisa A ; Agarwal, Neeraj ; Teerlink, Craig


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a570345.pdf


Report Date : Oct 2012


Pagination or Media Count : 12


Abstract : The first year of this grant has already resulted in an informative set of DNA, high risk pedigrees, and phenotype data for a set of pedigrees representing an excess of a highly significant clinic subset of prostate cancer cases: those who will go on to die of the disease. Our initial linkage analysis of less than 200 cases has already significantly confirmed a previously reported linkage on chromosome 1. In addition, our initial linkage analysis of less than 200 cases has already identified a significant linkage on chromosome 11. This initial linkage manuscript is in preparation. We will now collaborate (with other funding) to begin sequence analysis of the regions of interest. Identification of genes predisposing to recurrent/lethal prostate cancer from this study will validate this powerful approach, which can be extended to other high risk prostate cancer pedigrees, and will identify genes and pathways that can be further examined to expand our knowledge of prostate cancer genetics.


Descriptors :   *CHROMOSOMES , *DEOXYRIBONUCLEIC ACIDS , *GENES , *PROSTATE CANCER , GENETICS , IDENTIFICATION , LETHALITY , OUTPATIENT CLINICS , PATIENTS , RESPONSE(BIOLOGY) , SEQUENCES


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE