Accession Number : ADA569166


Title :   Center of Excellence for Individuation of Therapy for Breast Cancer


Descriptive Note : Final rept. 1 Apr 2011-31 Mar 2012


Corporate Author : INDIANA UNIV INDIANAPOLIS


Personal Author(s) : Sledge, Jr, George W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a569166.pdf


Report Date : Mar 2012


Pagination or Media Count : 57


Abstract : During the most recent period the Center of Excellence continued to collect and process human breast cancer tissues for patients receiving chemotherapy for metastatic disease. These tissues have been annotated clinically, examined by the study pathologist for QC/QA purposes, entered into our data analysis system, and distributed to the appropriate laboratory investigators for evaluation. An initial analysis of patients with metastatic breast cancer treated with the antimetabolite prodrug capecitabine was performed, and revealed striking correlations between thymidylate synthase (as measured by fluorescence in situ hybridization) and outcome.


Descriptors :   *BREAST CANCER , *CHEMOTHERAPY , DATA PROCESSING , DISEASES , FLUORESCENCE , GENOMICS , HYBRIDIZATION , MAMMARY GLANDS , METASTASIS , PATHOLOGISTS , PATIENTS , SYNTHASES , THERAPY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE