Accession Number : ADA568802


Title :   A Partnership Training Program: Studying Targeted Drug Delivery Using Nanoparticles in Breast Cancer Diagnosis and Therapy


Descriptive Note : Annual summary 15 Sep 2011-14 Sep 2012


Corporate Author : HOWARD UNIV WASHINGTON DC


Personal Author(s) : Wang, Paul C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a568802.pdf


Report Date : Oct 2012


Pagination or Media Count : 98


Abstract : In the second year of this training grant, 11 faculty members, 7 postdocs, 4 graduate and 6 undergraduate students from 6 departments at the Howard University have been trained in the use of nanoparticles as targeted drug delivery vehicles for cancer diagnosis and therapy. Ten seminars and workshops in cancer, molecular imaging, and nanomedicine have been offered. The trainees have received hands-on training in MRI, optical imaging, cell biology lab techniques, and small animal handling. The two research projects have progressed well. We have improved controlling the size of liposome with a heat sonic method. We studied the stability of surface coating of quantum dots as a model for studying potential toxicity of nanoparticles. We have shown that A-dmDT(390)-scfbDb(PSMA), a single chain Fv fragments of antibody with diphtheria toxin, demonstrates good dual targeted imaging and therapeutic properties. We have shown that a contrast agent encapsulated in liposome with transferrin as a targeting ligand has higher uptake in breast cancer cells and in tumor bearing animals. This year, there are 11 research projects utilizing the facility of the Nanomedicine Core. The Core has become a synergy center, drawing multidisciplinary research using nanotechnology for cancer research.


Descriptors :   *BREAST CANCER , BACTERIAL TOXINS , CELLS(BIOLOGY) , CORYNEBACTERIUM DIPHTHERIAE , DIAGNOSIS(MEDICINE) , DRUG SMUGGLING , THERAPY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE