Accession Number : ADA568374


Title :   Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks


Descriptive Note : Journal article


Corporate Author : MILITARY ACADEMY WEST POINT NY


Personal Author(s) : Shakarian, Paulo ; Wickiser, J K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a568374.pdf


Report Date : 21 Sep 2012


Pagination or Media Count : 8


Abstract : We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various shells based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.


Descriptors :   *PROTEINS , HUMANS , NETWORKS , PATHOGENIC MICROORGANISMS , PLANTS(BOTANY)


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE