Accession Number : ADA568358


Title :   Genome Wide Association Study to Identify SNPs and CNPs Associated with Development of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy


Descriptive Note : Final rept. 30 Sep 2008-29 Sep 2012


Corporate Author : MOUNT SINAI SCHOOL OF MEDICINE NEW YORK


Personal Author(s) : Rosenstein, Barry S ; Ostrer, Harry


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a568358.pdf


Report Date : Oct 2012


Pagination or Media Count : 47


Abstract : The hypothesis that forms the basis for this research is that patients who possess certain SNPs or CNPs are at a greater risk for developing severe urinary morbidity or erectile dysfunction (ED) resulting from radiotherapy for prostate cancer. The specific aim of this project was to identify through a genome wide association study the SNPs and CNPs associated with the development of these adverse effects resulting from the use of radiation to treat prostate cancer. We have performed a two-stage genome-wide association study and identified and validated loci associated with each of these primary outcomes. It is expected that the results of this work will provide the basis for a clinically relevant predictive test to identify patients at increased risk for development of adverse events following radiotherapy. It is anticipated that such a tool will be used to aid clinicians in personalizing treatment to improve the therapeutic outcome for men diagnosed with prostate cancer.


Descriptors :   *PROSTATE CANCER , DYSFUNCTION , GENOME , MORBIDITY , RADIATION , RADIOTHERAPY , RISK , TOXICITY , URINE


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE