Accession Number : ADA567826


Title :   Psychophysiology of Delayed Extinction and Reconsideration in Humans


Descriptive Note : Annual rept. 20 Jan 2011-19 Jan 2012


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Pitman, Roger


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a567826.pdf


Report Date : Feb 2012


Pagination or Media Count : 7


Abstract : Recent animal research suggests that reactivation (retrieval) of a consolidated memory can return it to a labile state from which it must be restabilized in order to persist. This stabilization process has been termed reconsolidation, and various behavioral and pharmacologic interventions have been found to modify or block it. The aim of this project is to create an experimental assay in the form of an optimal Pavlovian differential fear conditioning paradigm, within which the relative strengths of various novel pharmacological and behavioral, reconsolidation-blocking interventions can be tested. Thus far, we have successfully implemented the procedure, and are meeting or nearly meeting our recruitment goals. We have validated the novel fear conditioning paradigm by demonstrating differential conditioning in participants. Data collected to date have been subjected to preliminary analysis .Although several interesting trends are present, it is too early to draw conclusions. Subjects are continuing to be studied.


Descriptors :   *POST TRAUMATIC STRESS DISORDER , *PSYCHOPHYSIOLOGY , BEHAVIOR , INFORMATION RETRIEVAL , MEMORY DEVICES , RECRUITING , STABILIZATION


Subject Categories : Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE