Accession Number : ADA566666


Title :   Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury


Descriptive Note : Final rept. 1 Jun 2009-31 May 2011


Corporate Author : LOMA LINDA UNIV CA


Personal Author(s) : Obenaus, Andre


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a566666.pdf


Report Date : Jun 2011


Pagination or Media Count : 120


Abstract : To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (NAD). Scope: In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.


Descriptors :   *TRAUMATIC BRAIN INJURIES , HISTOLOGY , HYPERBARIC CONDITIONS , MAGNETIC RESONANCE IMAGING , PREVENTIVE MEDICINE , RATS , TEST AND EVALUATION , THERAPY , TRACER STUDIES


Subject Categories : Biochemistry
      Medicine and Medical Research
      Weapons Effects(biological)


Distribution Statement : APPROVED FOR PUBLIC RELEASE