Accession Number : ADA563338


Title :   Blast Injuries And Heterotopic Ossification


Descriptive Note : Journal article


Corporate Author : WALTER REED NATIONAL MILITARY MEDICAL CENTER BETHESDA MD


Personal Author(s) : Alfieri, K A ; Forsberg, J A ; Potter, B K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a563338.pdf


Report Date : Aug 2012


Pagination or Media Count : 7


Abstract : Heterotopic ossification (HO) is perhaps the single most significant obstacle to independence, functional mobility, and return to duty for combat-injured veterans of Operation Enduring Freedom and Operation Iraqi Freedom. Recent research into the cause(s) of HO has been driven by a markedly higher prevalence seen in these wounded warriors than encountered in previous wars or following civilian trauma. To that end, research in both civilian and military laboratories continues to shed light onto the complex mechanisms behind HO formation, including systemic and wound specific factors, cell lineage, and neurogenic inflammation. Of particular interest, non-invasive in vivo testing using Raman spectroscopy may become a feasible modality for early detection, and a wound-specific model designed to detect the early gene transcript signatures associated with HO is being tested. Through a combined effort, the goals of early detection, risk stratification, and development of novel systemic and local prophylaxis may soon be attainable


Descriptors :   *BLAST WAVES , *PREVENTIVE MEDICINE , *WOUNDS AND INJURIES , AMPUTATION , IN VIVO ANALYSIS , INFLAMMATION , JOBS , MILITARY FACILITIES , MOBILITY , NERVOUS SYSTEM , RAMAN SPECTROSCOPY , RISK , TEST AND EVALUATION , TRAUMA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE