Accession Number : ADA562114


Title :   Ketamine as a Rapid Treatment for Post-Traumatic Stress Disorder


Descriptive Note : Annual rept. 15 Sep 2010-14 Sep 2011


Corporate Author : MOUNT SINAI SCHOOL OF MEDICINE NEW YORK


Personal Author(s) : Charney, Dennis


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a562114.pdf


Report Date : Oct 2011


Pagination or Media Count : 5


Abstract : Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder characterized by intrusive re-experiencing of the traumatic events, avoidance of situations and stimuli that could serve as reminders of these events, and chronic hypervigilance. Patients with PTSD are often also depressed, and many have significant memory impairments. In the present study, we expect a single ketamine infusion to reduce core PTSD symptoms. In addition, in those patients with PTSD who are depressed, we expect ketamine to reduce depressed mood. Finally, ketamine is known to impair memory function. We will also test if the extent of ketamine-induced memory impairment during the infusion can predict how well people do after the infusion. The first patient was randomized at the end of May 09 as recruitment began in March 09. To date, 31 people have been randomized of which 26 have completed study procedures.


Descriptors :   *ANXIETY , *POST TRAUMATIC STRESS DISORDER , DEGRADATION , INFUSIONS , MEMORY DEVICES , MEMORY(PSYCHOLOGY) , PATIENTS , STRESS(PHYSIOLOGY) , TRAUMA


Subject Categories : Psychology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE