Accession Number : ADA561078


Title :   Differential Expression of Zinc Transporters in Prostate Epithelia of Racial Groups


Descriptive Note : Annual rept. 1 Sep 2009-31 Aug 2010


Corporate Author : ILLINOIS UNIV AT CHICAGO


Personal Author(s) : Kajdacsy-Balla, Andre


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a561078.pdf


Report Date : Sep 2010


Pagination or Media Count : 21


Abstract : In the award (W81XWH-08-1-0627) the stated goals are to study the zinc transporters that may be disparately expressed in the prostate tissues of African American (AA) males as compared to European American (EA) males. This may lead to identification of the potential molecular targets for preventive or therapeutic measures or nutritional, environmental or life style factors for their potential relationship to the incidence or progression of prostate cancer in various racial groups. The following tasks are to be carried out in a synergistic fashion between the laboratories of Dr. Bagasra (Claflin University) and Dr. Balla (University of Illinois, Chicago). The prostate tissues, pre-made tissue microarrays (TMAs) and primary cell lines will be obtained from the NCI -initiated Cooperative Prostate Cancer Tissue Resource (CPCTR) by Dr. Balla, one of the P.I.s of the present proposal and of the CPCTR. The main tissue microarray being used is composed of age-matched and the Gleason score-matched prostate tissues with representative tissues from 150 African Americans and 150 European American racial groups. Other TMAs are also used to address questions of whether hZIP gene and protein expression is associated with poor outcome and/or Gleason grade. Significant progress has been made in each of the three TASKS proposed. So far we have two peerreviewed publications as well as numerous oral and poster presentations have resulted. We also have three additional publications in preparation for peer-review journals.


Descriptors :   *AFRICAN AMERICANS , *GENES , *PROSTATE CANCER , *ZINC , CARGO VEHICLES , CELLS(BIOLOGY) , EPITHELIUM , EUROPE , ORAL INTAKE , PROSTATE GLAND , PROTEINS , RACE(ANTHROPOLOGY) , SYNERGISM , THERAPY , TISSUES(BIOLOGY)


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE