Accession Number : ADA560649


Title :   Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury


Descriptive Note : Annual rept. 27 Sep 2010-26 Sep 2011


Corporate Author : BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA


Personal Author(s) : Hackney, David


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a560649.pdf


Report Date : Oct 2011


Pagination or Media Count : 29


Abstract : During the first year we pursued studies of q-space imaging (QSI) of the spinal cord and myelin imaging. The QSI studies extended our previous work establishing our ability to define the distribution of axon fiber diameters using this noninvasive approach. This work was presented at the Annual Meeting of the International Society of Magnetic Resonance in Medicine in Montreal, May, 2011. In addition, we made great progress with an ultra-short TE (UTE) method for myelin imaging. Using this approach we were able to establish quantitative accuracy vs. MR spectroscopy and preparations with known myelin content. This method holds promise for extension to human subjects, and it could offer a unique opportunity to observe myelin without confounding by other axonal injury or edema. This work was presented at the Annual Meeting of the International Society of Magnetic Resonance in Medicine in Montreal, May, 2011, and at the Annual Meeting of the American Society of Neuroradiology in Seattle, June, 2011. A revised manuscript is currently under review at the Proceedings of the National Academy of Sciences.


Descriptors :   *MAGNETIC RESONANCE IMAGING , *SPINAL CORD , *WOUNDS AND INJURIES , DIAMETERS , MEDICINE , NERVE FIBERS , SHEATHS(ANATOMY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE