Accession Number : ADA559237


Title :   Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alterations in CNS Development


Descriptive Note : Annual rept. 15 Sep 2010-14 Sep 2011


Corporate Author : ARKANSAS CHILDREN'S HOSPITAL LITTLE ROCK AR


Personal Author(s) : James, Sandra J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a559237.pdf


Report Date : Oct 2011


Pagination or Media Count : 32


Abstract : We hypothesize that low systemic redox potential (GSH/GSSG; cysteine/cystine) reflects a vulnerability phenotype that is associated with regressive autism and is predictive of the risk of developing autism. The redox vulnerability phenotype is associated with epigenetic alterations in primary immune cells that may be reversible with restoration of intracellular redox potential. The hypothesis predicts that children with regressive autism and high risk (developmentally-delayed) children who are subsequently diagnosed with autism will exhibit lower redox potential compared to age-matched unaffected control children. It also predicts that low redox potential from these children will be associated with epigenetic modifications in DNA methylation and histone acetylation/methylation that are reversible with treatment to restore redox potential. In Aim 1 we will determine whether redox potential in immune cells can be used as a biomarker for regressive autism and whether it is predictive of the subsequent diagnosis of autism. We will also evaluate immune redox potential from high risk developmentally delayed children to determine whether redox status is predictive of subsequent development of autism. In Aim 2, we will determine whether immune cells from autistic children are associated with altered cytokine patterns, macrophage/T cell DNA methylation, and chromatin histone methylation compared to control children


Descriptors :   *ABNORMALITIES , *CENTRAL NERVOUS SYSTEM , *CHILDREN , *CYSTEINE , ACETYLATION , CELLS(BIOLOGY) , CYSTINE , CYTOKINES , DEOXYRIBONUCLEIC ACIDS , GENETIC ENGINEERING , HISTONES , HYPOTHESES , IMMUNITY , METHYLATION , OXIDATION REDUCTION REACTIONS , RISK


Subject Categories : Psychology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE