Accession Number : ADA558802


Title :   Oxygenation-Enhanced Radiation Therapy of Breast Tumors


Descriptive Note : Final rept. 1 Sep 2010-31 Oct 2011


Corporate Author : UTAH UNIV SALT LAKE CITY


Personal Author(s) : Skliar, Mikhail


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a558802.pdf


Report Date : Nov 2011


Pagination or Media Count : 29


Abstract : The treatment of locoregional breast cancer has evolved from radical mastectomy to targeted local therapy with breast conservation. The efficacy of conserving treatments of breast cancers is impeded by tumor hypoxia, which affects 50% of locally advanced breast tumors. Poor oxygenation of hypoxic tumors reduces their sensitivity to X-ray and -radiation, which requires a high radiation dose for efficacy compared to normally oxygenated tissues. This Concept project provides initial investigation the method for targeted oxygen release from oxygen carriers as a step towards as a novel strategy of radio sensitization of hypoxic breast tumors, and studies the effect of different targeting mechanisms on the oxygen mass transfer. Specific results include the development of stabilized perfluorocarbon emulsions as oxygen carriers, their characterization, and response to external triggers, including elevated temperature, reduced pressure, and dwell time.


Descriptors :   *BREAST CANCER , *OXYGEN , *RADIATION DOSAGE , CONSERVATION , DWELL TIME , EMULSIONS , FLUORINATED HYDROCARBONS , HYPOXIA , MAMMARY GLANDS , NEOPLASMS , RADIOTHERAPY , SENSITIVITY , TISSUES(BIOLOGY) , TRIGGER CIRCUITS


Subject Categories : Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE