Accession Number : ADA558524


Title :   Treatment of Laser-Induced Retinal Injury and Visual Loss Using Sustained Release of Intra-Vitreal Neurotrophic Growth Factors. Addendum


Descriptive Note : Final addendum rept. 24 Sep 2010-23 Oct 2011


Corporate Author : IOWA UNIV IOWA CITY


Personal Author(s) : Kardon, Randy


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a558524.pdf


Report Date : Nov 2011


Pagination or Media Count : 51


Abstract : Laser injury to the superior or inferior region of the retina results in structural and functional retina deficits. Damage to the superior retina resulted in an intrinsic up- regulation of brain- derived neurotrophic factor (BDNF), glial cell- line derived neurotrophic factor (GDNF) and a trend towards increased ciliary neurotrophic factor (CNTF) expression between three and 14 days after injury. Intravitreal injection of growth factor- containing seemed to have some protective effect on both structural and functional properties of rods in laser- injured retinas. GDNF was somewhat more effective when compared to CNTF. However, GDNF seemed to have a negative effect on cone function (decreased photopic a- and bwaves and photopic flicker response). Even though GDNF preserved peripapillary nerve fiber layer thickness, none of the growth factors had positive effect on the function of retinal ganglion cells. On the contrary, both CNTF and GDNF seemed to have additional negative effect in addition to laser damage on RGC function. The endogenous expression of GDNF and BDNF were significantly correlated with several functional and structural retinal parameters.


Descriptors :   *GROWTH(PHYSIOLOGY) , *RETINA , *VISION , *WOUNDS AND INJURIES , CELLS(BIOLOGY) , CILIA , DAMAGE , GANGLIA , NERVE CELLS , NERVE FIBERS


Subject Categories : Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE