Accession Number : ADA558405


Title :   Transforming Growth Factor Beta Signaling in Growth of Estrogen-Insensitive Metastatic Bone Lesions


Descriptive Note : Annual summary 15 Dec 2008-14 Dec 2011


Corporate Author : INDIANA UNIV INDIANAPOLIS


Personal Author(s) : Nickerson, Nicole


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a558405.pdf


Report Date : Jan 2012


Pagination or Media Count : 99


Abstract : While many women with breast cancer will use estrogen receptor therapeutics such as fulvestrant, resistance is nearly inevitable. Recently, it has been noted that the epidermal growth factor receptor (EGFR) family plays a vital role in metastasis to bone; also cross signaling with the transforming growth factor receptor type II (TGFBR2) has been noted to increase levels of destructive environmental cytokines. Therefore we are examining the role of EGFR/TGFBR2 cross talk in bone metastatic breast cancer. The study of these pathways are important to metastatic breast cancer, as they have been known to increase levels of the destructive cytokine parathyroid hormone related protein (PTHrP), which causes increased osteolysis within the bone environment. To elucidate the connection between these two vital receptors may led to further progression in therapeutics for those women with EGFR positive tumors.


Descriptors :   *BONES , *BREAST CANCER , *METASTASIS , *RECEPTOR SITES(PHYSIOLOGY) , CYTOKINES , EPIDERMIS , ESTROGENS , GROWTH(GENERAL) , LESIONS , NEOPLASMS , OSTEOLYSIS , PARATHYROID HORMONES , PROTEINS , RESISTANCE , SENSE ORGANS , THERAPY , WOMEN


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE