Accession Number : ADA557574


Title :   Odorant Receptor Modulation: Ternary Paradigm for Mode of Action of Insect Repellents


Descriptive Note : Journal article


Corporate Author : AGRICULTURAL RESEARCH SERVICE BELTSVILLE MD


Personal Author(s) : Bohbot, Jonathan D ; Dickens, Joseph C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a557574.pdf


Report Date : Jan 2012


Pagination or Media Count : 11


Abstract : The modulation of insect behavior for the purpose of controlling the spread of infectious diseases has been the task of a few insect repellents for which the mechanistic modes of action on odorant receptors (ORs) are unclear. Here, we study the effects of the repellents DEET and IR3535, and a novel OR coreceptor (Orco) agonist on odorant-evoked currents in Xenopus oocytes expressing two subtypes of Aedes aegypti ORs (AaORs).We show that DEET and IR3535 behave as insurmountable antagonists of ORs and that modulation of OR activity is not restricted to antagonism and agonism, but also includes synergism. This knowledge of the molecular mechanisms underlying OR blockade, activation and hyperactivation will be fundamental to the development of novel strategies for the control of mosquito behavior.


Descriptors :   *AEDES , *INSECT REPELLENTS , BEHAVIOR , DISEASES , PHARMACOLOGICAL ANTAGONISTS , STRATEGY


Subject Categories : Animal Husbandry and Veterinary Medicine


Distribution Statement : APPROVED FOR PUBLIC RELEASE