Accession Number : ADA556142


Title :   Fish Oil Supplementation and Fatty Acid Synthase Expression in the Prostate: A Randomized Controlled Trial. Addendum


Descriptive Note : Final addendum rept. 1 Mar 2010-30 Jun 2011


Corporate Author : OREGON HEALTH AND SCIENCE UNIV PORTLAND


Personal Author(s) : Shannon, Jackilen


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a556142.pdf


Report Date : Jul 2011


Pagination or Media Count : 13


Abstract : One in seven men over the age of 60 will be diagnosed with prostate cancer. Elucidation of early cellular changes that may predict progression to prostate cancer and the identification of factors that may inhibit or reverse these cellular changes would be of great clinical significance. Alteration of the fatty acid synthase (FAS) pathway is an early cellular change that has recently come under investigation. Overexpression of the lipogenic enzyme FAS has been noted in several tumor and pre-cancerous tissue types, including prostatic intraepithelial neoplasia (PIN) and prostate cancer and has been suggested as an independent predictor of disease stage. Additionally, inhibition of FAS has been demonstrated to induce apoptosis and reduce cell proliferation in cancer cells. Fatty acid synthase expression in cancer and normal cells is regulated by the transcription factor sterol regulatory element binding protein 1c (SREBP-1). The up-regulation of SREBP-1 in tumor cells results in increased FAS expression and fatty acid synthesis. Research in normal cells has demonstrated that dietary supplementation with polyunsaturated fatty acids (PUFA), particularly omega-3 fatty acids, inhibits SREBP-1 activation, resulting in a decreased transcription of FAS.


Descriptors :   *FATTY ACIDS , *PROSTATE CANCER , APOPTOSIS , CHEMICAL BONDS , CLINICAL MEDICINE , CLINICAL TRIALS , FISH OILS , IDENTIFICATION , LIPID METABOLISM , NEOPLASMS , PROSTATE GLAND , SYNTHASES , SYNTHESIS(CHEMISTRY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE