Accession Number : ADA555446


Title :   Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multiethnic Cohort Experience


Descriptive Note : Final rept. 4 Sep 2007-3 Sep 2011


Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX


Personal Author(s) : Strom, Sara


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a555446.pdf


Report Date : Oct 2011


Pagination or Media Count : 62


Abstract : Most prostate cancer(PCa) research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicity/race. There are strong racial disparities in mortality with African-Americans twice as likely to die from PCa comparedto Caucasians; very little data are available in Hispanics. Our goal was to identify markers of PCa progression in a multiethnic cohort(773 Caucasians, 361 African-Americans & 246 Mexican-Americans). Medical records for all participants have been abstracted, and we have updated vital status using the National Death Index. Using DNA extracted from archived specimens, we utilized a genome wide association study approach to identify polymorphisms associated with PCa progression; this approach has lead to the identification of different polymorphisms to be relevant in Caucasians vs. African- Americans. These results may offer insight into racial/ethnic differences in PCa progression and may be used to develop racespecific models for PCa progression.


Descriptors :   *PROSTATE CANCER , *RACE RELATIONS , CAUCASIANS , DEATH , DEOXYRIBONUCLEIC ACIDS , ETHNIC GROUPS , GROWTH(PHYSIOLOGY) , HISPANICS , IDENTIFICATION , MEDICINE , MORTALITY RATE , POLYMORPHISM , PROSTATE GLAND


Subject Categories : Sociology and Law
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE