Accession Number : ADA555406


Title :   Coordination of BRCA1/BARD1- and MRE11/RAD50/NBS1-Dependent DNA Transactions in Breast Tumor Suppression


Descriptive Note : Final rept. 1 Jul 2008-30 Jun 2011


Corporate Author : COLUMBIA UNIV NEW YORK


Personal Author(s) : Gautier, Jean


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a555406.pdf


Report Date : Jul 2011


Pagination or Media Count : 56


Abstract : The main objective of the proposal is to understand how the Mre11-Rad50-Nbs1 complex and the BRCA1-BARD1 complex interact on DNA and coordinate DNA transactions that are critical for the maintenance of genomic stability and to prevent breast tumor development. We have characterized the behavior of BRCA1/BARD1 on DNA, using a single molecule approach. We have developed new single molecule technologies to study the behavior of BRCA1/BARD1 and MRN complexes. Finally, we have established that MRN-BRAC1/BARD1 interactions are dispensable for MRN/CtIP dependent DNA end resection, the first step of homology-dependent repair of DNA double-strand breaks.


Descriptors :   *BREAST CANCER , BEHAVIOR , DEOXYRIBONUCLEIC ACIDS , MAMMARY GLANDS , NEOPLASMS , REPAIR , SUPPRESSION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE