Accession Number : ADA555154


Title :   Etiology of Acute, Non-Malaria, Febrile Illnesses in Jayapura, Northeastern Papua, Indonesia


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH UNIT NO 2 DETACHMENT JAKARTA (INDONESIA)


Personal Author(s) : Punjabi, Narain H ; Taylor, Walter R ; Murphy, Gerald S ; Purwaningsih, Sri ; Picarima, Helena ; Sisson, John ; Olson, James G ; Baso, Samuel ; Wangsasaputra, Ferry ; Lesmana, Murad


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a555154.pdf


Report Date : Jan 2012


Pagination or Media Count : 7


Abstract : We conducted a prospective, inpatient fever study in malaria-endemic Papua, Indonesia to determine nonmalaria fever etiologies. Investigations included malaria blood films, blood culture, paired serologic samples analysis for dengue, Japanese encephalitis, leptospirosis, scrub typhus, murine typhus, and spotted fever group rickettsia. During 1997 2000, 226 patients (127 males and 99 females) 1 80 years of age (median age = 25 years) were enrolled. Positive blood cultures (n = 34, 15%) were obtained for Salmonella Typhi (n = 13), Escherichia coli (n = 8), Streptococcus pneumoniae (n = 6), Staphylococcus aureus (n = 5), Streptococcus pyogenes (n = 1), and Klebsiella pneumoniae (n = 1). Twenty (8.8%) patients were positive for leptospirosis by polymerase chain reaction. Eighty (35.4%) of 226 patients had 1 positive serology, diagnostic for 15 rickettsial and 9 dengue cases. Acid-fast bacilli positive sputum was obtained from three patients. Most common confirmed (81 of 226, 35.8%)/suspected diagnoses were typhoid fever (n = 41), pneumonia (n = 29), leptospirosis (n = 28), urinary tract infections (n = 20), rickettsioses (n = 19), dengue (n = 17), and meningitis/encephalitis (n = 15). There were 17 deaths, 7 (46.7%) were caused by meningitis/encephalitis. Multiple positive serologic results and few confirmed diagnoses indicate the need for improved diagnostics.


Descriptors :   *BLOOD DISEASES , *ETIOLOGY , *FEVERS , *ILLNESS , *KLEBSIELLA PNEUMONIAE , *MALARIA , *SEROLOGY , CHAIN REACTIONS , ESCHERICHIA COLI , INDONESIA , INFECTIOUS DISEASES , JAPANESE ENCEPHALITIS , LEPTOSPIROSIS , MENINGITIS , PATIENTS , PNEUMONIA , REPRINTS , RICKETTSIA , RICKETTSIA RICKETTSII , SALIVA , SALMONELLA TYPHI , SCRUB TYPHUS , STAPHYLOCOCCUS AUREUS , STREPTOCOCCUS , STREPTOCOCCUS PYOGENES , TYPHOID , TYPHUS , URINARY SYSTEM


Subject Categories : Medicine and Medical Research
      Ecology


Distribution Statement : APPROVED FOR PUBLIC RELEASE