Accession Number : ADA554107


Title :   A New Perspective on Radiation Resistance Based on Deinococcus radiodurans


Descriptive Note : Journal article


Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF PATHOLOGY


Personal Author(s) : Daly, Michael J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a554107.pdf


Report Date : Mar 2009


Pagination or Media Count : 10


Abstract : In classical models of radiation toxicity, DNA is the molecule that is most affected by ionizing radiation (IR). However, recent data show that the amount of protein damage caused during irradiation of bacteria is better related to survival than to DNA damage. In this Opinion article, a new model is presented in which proteins are the most important target in the hierarchy of macromolecules affected by IR. A first line of defence against IR in extremely radiation-resistant bacteria might be the accumulation of manganese complexes, which can prevent the production of iron-dependent reactive oxygen species. This would allow an irradiated cell to protect sufficient enzymatic activity needed to repair DNA and survive.


Descriptors :   *BACTERIA , *RADIATION RESISTANCE , DEOXYRIBONUCLEIC ACIDS , IONIZING RADIATION , MANGANESE , PROTEINS , REPRINTS


Subject Categories : Radiobiology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE