Accession Number : ADA554084


Title :   TSC Regulates Oligodendroglial Differentiation and Myelination in the CNS


Descriptive Note : Annual rept. 15 Aug 2010-14 Aug 2011


Corporate Author : UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK


Personal Author(s) : Wood, Teresa


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a554084.pdf


Report Date : Sep 2011


Pagination or Media Count : 37


Abstract : The basis of the proposed research is to investigate a novel idea that some of the underlying cause of brain abnormalities in TSC is due to disruption of the oligodendrocytes and production of the myelin wrapping; this in turn leads to alterations in the neurons and their ability to signal properly to other neurons. Proper communication between the oligodendrocytes and the axons is necessary for normal brain development. The oligodendrocytes receive signals from the axons to initiate myelination and to wrap the axon properly. In turn, the formation of the myelin wrapping allows communication between neurons and refinement of neuronal and brain function during development. Data accumulating from these studies indicate that disruption of TSC in primary rat oligodendrocyte progenitors in vitro alters the differentiation and myelination program in these cells. The altered development of the myelin-producing cells may interfere with the ability of the neurons to develop and function normally.


Descriptors :   *BRAIN , *CENTRAL NERVOUS SYSTEM , *NERVE CELLS , *SIGNS AND SYMPTOMS , ABNORMALITIES , COMMUNICATION AND RADIO SYSTEMS , FUNCTIONS , HYPOTHESES , IN VITRO ANALYSIS , NERVE FIBERS , ORGANS(ANATOMY) , PATIENTS , SHEATHS(ANATOMY)


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE