Accession Number : ADA553962


Title :   Dual-Modality Prostate Imaging with PET and Transrectal Ultrasound


Descriptive Note : Final rept. 15 Mar 2007-30 Aug 2011


Corporate Author : CALIFORNIA UNIV BERKELEY


Personal Author(s) : Huber, Jennifer


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a553962.pdf


Report Date : Sep 2011


Pagination or Media Count : 53


Abstract : We developed the hardware and software tools needed for dual Positron Emission Tomography-Transrectal Ultrasound (PET-TRUS) imaging of the prostate. We modified the TRUS equipment to work when mounted on a scanner table in conjunction with both the LBNL prostate-optimized and Siemens EXACT HR PET scanners. We developed software to: determine the location of point sources and calculate the corresponding location of the TRUS probe tip (both in PET coordinates), reconstruct PET data, reslice PET imaging data into TRUS coordinates, and display fused PET-TRUS images. We validated methods for positioning a subject's prostate in the center of the PET scanner. We also constructed and imaged one-of-a-kind PET-TRUS phantoms, using these phantoms to evaluate our dual PET-TRUS imaging techniques. Based on this phantom imaging, we currently have a PET-TRUS registration error of -2.1 plus or minus 1.7 mmin the x direction, 1.9 plus or minus 1.6 mm in the y direction, and 0.6 plus or minus 0.2 mm in the z direction. We also performed extensive point source, phantom and mechanical tests to investigate our PET-TRUS registration accuracy. Finally, we updated our IRB approval for human subject studies to improve subject recruitment, unfortunately without success.


Descriptors :   *PROSTATE CANCER , COMPUTER PROGRAMS , COORDINATES , DISPLAY SYSTEMS , DUAL MODE , IMAGES , MECHANICAL PROPERTIES , MOUNTS , POSITION FINDING , POSITRONS , PROBES , PROSTATE GLAND , RECRUITING , SCANNERS , SOFTWARE TOOLS , TEST AND EVALUATION , ULTRASONICS , VALIDATION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE