Accession Number : ADA552450


Title :   Reconstructing the Prostate Cancer Transcriptional Regulatory Network


Descriptive Note : Annual summary, 1 Jun 2009-30 Sep 2010


Corporate Author : LELAND STANFORD JUNIOR UNIV CA


Personal Author(s) : Salari, Keyan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a552450.pdf


Report Date : Sep 2010


Pagination or Media Count : 36


Abstract : This award has enabled the development of computational methods to analyze and integrate diverse prostate cancer genomic datasets. We have successfully applied our newly-developed methods to a prostate cancer dataset, resulting in the identification of genes that may play a causal role in prostate tumor metastasis. Our analysis of prostate tumor DNA copy number data has also uncovered a potentially novel tumor suppressor gene associated with clinically-indolent prostate cancer. This finding may represent a much-needed biomarker capable of distinguishing indolent versus aggressive disease, and may lead to novel strategies for patient management.


Descriptors :   *GENOMICS , *PROSTATE CANCER , DEOXYRIBONUCLEIC ACIDS , GENE EXPRESSION


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE