Accession Number : ADA552326


Title :   Hemoglobin-based Oxygen Carrier (HBOC-201) and Escalating Doses of Recombinant Factor VIla (rFVIIa) as a Novel Pre-hospital Resuscitation Fluid in a Swine Model of Severe Uncontrolled Hemorrhage


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD


Personal Author(s) : Scultetus, Anke ; Arnaud, Francoise ; Kaplan, Lewis ; Shander, Aryeh ; Philbin, Nora ; Rice, Jennifer ; McCarron, Richard ; Freilich, Daniel


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a552326.pdf


Report Date : Jan 2011


Pagination or Media Count : 11


Abstract : Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 J.lg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and I 80 J.lg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 J.lg/kg group. Verification in a large, well-powered study is indicated.


Descriptors :   *BLOOD DISEASES , *DOSAGE , *LIVER , *LOSSES , *SWINE , *WOUNDS AND INJURIES , BLOOD , HEMORRHAGE , HOSPITALS , LACTATES , OXYGEN , RESUSCITATION , TRAUMA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE