Accession Number : ADA552313


Title :   Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT


Personal Author(s) : McKenzie, Robin ; Porter, Chad K ; Cantrell, Joyce A ; DeNearing :Aisling, Barbara ; Grahek, Shannon L ; Sincock, Stephanie A ; Woods, Colleen ; Sebeny, Peter ; Sack, David A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a552313.pdf


Report Date : 01 Jul 2011


Pagination or Media Count : 6


Abstract : Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CSI7 and CSI9. LSN03-016011/A (LT, CS17) elicited a dosedependent effect, with the upper dose (6 X 10(exp 9) organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CSI9) also showed a dose response, with a 44% diarrhea rate at 9 X 10(exp 9 organisms. Both strains elicited homologous antifimbrial and anti-L T antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT!CS17-ETEC challenge model for interventional trials.


Descriptors :   *COLONIES(BIOLOGY) , *ENTEROTOXINS , *ESCHERICHIA COLI , DOSAGE , INTESTINES , PATHOGENESIS , REPORTS , RESPONSE(BIOLOGY) , STRAINS(BIOLOGY) , VOLUNTEERS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE